An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils
نویسندگان
چکیده
منابع مشابه
An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils
Interleukin 5 (IL-5) is the key cytokine involved in regulating the production and many of the specialized functions of mature eosinophils including priming, adhesion, and survival. We have generated a point mutant of human IL-5, IL-5 (E12K), which is devoid of agonist activity in both a TF-1 cell proliferation assay and a human eosinophil adhesion assay. However, IL-5 (E12K) is a potent and sp...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.186.1.121